CD 4+ T cells in the pathobiology of neurodegenerative disorders

Changes in Naive CD 4 T Cells

In the elderly, a dramatic shift within the CD4 + T cell population occurs, with an increased proportion having a memory phenotype with markedly decreased responsiveness. To determine what aspects o f the aged phenotype are dependent upon repeated contact with antigen in the environment, we examined CD4 + cells isolated from TC1L Tg n'nce. There is good evidence that no cross-reacting antigens ...

o f CD 4 Lineage T Cells

Thymocytes must bind major histocompatibility complex (MHC) proteins on thymic epithelial cells in order to mature into either CD8 + cytotoxic T cells or CD4 + helper T cells. Thymic precursors express both CD8 and CD4, and it has been suggested that the intracellular signals generated by CD8 or CD4 binding to class I or II M H C , respectively, might influence the fate o f uncommitted cells. H...

T Cells from Naive CD 4 T Cells CD 28 Controls Differentiation of Regulatory

Cellthe Peripheral Activated / Memory CD 4 T Regulatory CD 4 T Cells Control

Nonregulatory ) T Cells − CD 25 + ( Regulatory ) versus CD 4 + CD 25 + CD 4 Platelet Factor 4 Differentially Modulates